The production of beta-lactamases, enzymes that degrade the beta-lactam ring of the beta-lactam family of antibiotics, are a common resistance mechanism found in Gram-negative bacteria, particularly Enterobacterales.
There are different classes of beta-lactamase, each of which has a different spectrum of activity. The CTX-M class of beta-lactamases is important due to the extended spectrum of activity against penicillins and cephalosporins, including third generation cephalosporins. This makes Gram-negative bacteria that carry CTX-M enzymes more difficult to treat, requiring broader spectrum agents, such as piperacillin/tazobactam.
The NG Biotech CTX-M MULTI tests are an important tool that identify one of the important mechanisms of resistance to cephalosporins commonly found in Enterobacterales and inform appropriate prescribing #antimicrobialstewardship.
NG-Test CTX-M multiplex detects variants belonging to all five known CTX-M groups: 1, 2, 8, 9 & 25.
NG Biotech – AMR Range Brochure – Rapid detection and differentiation of expressed resistance mechanisms (AMR)
NG Biotech – AMR Range – Selection of peer reviewed publications about the NG Tests
Una Health White Paper – Lateral flow testing in an antimicrobial resistance pandemic
No downloads found