NG Biotech MCR-1
For rapid detection of mobilised colistin resistance.
A valuable tool to help determine the nature of resistance among colistin-resistant Gram-negative bacteria.
The NG-Test® MCR-1 aids in the rapid identification of bacteria carrying the mobilised colistin resistance gene, mcr-1, in Enterobacterales, Pseudomonas aeruginosa and Acinetobacter spp. in healthcare settings.
Easy to implement into any laboratory setting with minimal training, the NG-Test MCR-1 aids in informing appropriate antimicrobial therapeutic choices and supports prompt infection control decision-making and interventions.
Product Overview
NG-Test® MCR-1 is a qualitative lateral flow immunoassay for the rapid detection of Colistin resistance, in less than 15 minutes.
The in-vitro diagnostic test detects the presence of the MCR-1 enzyme responsible for Polymyxin E (colistin) resistance in Gram Negative bacteria, from a bacterial colony.
In terms of multidrug-resistant Gram-negative bacteria, colistin may be the only antibiotic to which the bacteria exhibit susceptibility, making it the last option available for treatment.
Colistin resistance is intrinsic in some bacterial species, such as Serratia and Proteus species. Resistance to colistin may arise due to chromosomal mutations; however, the advent of colistin resistance associated with a mobile genetic element (plasmid) is of serious concern.
The mcr gene, mobilised colistin resistance, encodes a phosphoethanolamine transferase that modifies the structure of the outer membrane of Gram-negative bacteria and decreases the activity of colistin against bacterial cells. The carriage of the mcr gene on mobile genetic elements means that there is a risk that colistin resistance will spread among other bacteria, including those that are resistant to all other classes of antibiotic.
The NG-Test MCR-1 test is an important tool that identifies an important mechanism of resistance to colistin to inform appropriate prescribing #antimicrobialstewardship and infection prevention actions.
Resources:
NG Biotech – AMR Range Brochure – Rapid detection and differentiation of expressed resistance mechanisms (AMR)
NG Biotech – AMR Range – Selection of peer reviewed publications about the NG Tests
Una Health White Paper – Lateral flow testing in an antimicrobial resistance pandemic
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